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Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun
《化学科学与工程前沿(英文)》 2018年 第12卷 第2期 页码 283-295 doi: 10.1007/s11705-017-1687-2
关键词: Alzheimer’s disease amyloid β-protein cyclic peptide inhibition protein aggregation
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 433-444 doi: 10.1007/s11705-014-1454-6
关键词: Alzheimer’s disease amyloid β-protein peptide inhibitors protein-protein interaction molecular dynamics simulation
Cystine oligomers successfully attached to peptide cysteine-rich fibrils
Christian Bortolini,Mingdong Dong
《化学科学与工程前沿(英文)》 2016年 第10卷 第1期 页码 99-102 doi: 10.1007/s11705-016-1554-6
关键词: cysteine peptide fibrils gold nanoparticles amyloids oligomers nanomaterials
Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 368-373 doi: 10.1007/s11684-015-0403-1
Glucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 μg GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P<0.001), whereas GLP-2 pretreatment significantly decreased their levels (P<0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.
关键词: ischemia/reperfusion liver glucagon-like peptide-2 alanine aminotransferase
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 437-442 doi: 10.1007/s11684-009-0074-x
关键词: natriuretic peptide precursor A coronary heart disease gene polymorphism allelic discrimination polymorphism single nucleotide
Mohammad Reza AZADI KAKAVAND, Ertugrul TACIROGLU
《结构与土木工程前沿(英文)》 2020年 第14卷 第6期 页码 1531-1544 doi: 10.1007/s11709-020-0675-7
关键词: damage plasticity model plain concrete cyclic loading multiaxial loading conditions
Isogeometric analysis of coupled thermo-elastodynamic problems under cyclic thermal shock
Asghar AMANI DASHLEJEH
《结构与土木工程前沿(英文)》 2019年 第13卷 第2期 页码 397-405 doi: 10.1007/s11709-018-0473-7
关键词: isogeometric analysis coupled thermo-elastodynamic dynamic analysis generalized newmark cyclic thermal shock
Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 9-19 doi: 10.1007/s11705-013-1306-9
关键词: insulin cell penetrating peptide mucoadhesive composites oral delivery
Liang-Jiu JIA, Tsuyoshi KOYAMA, Hitoshi KUWAMURA
《结构与土木工程前沿(英文)》 2013年 第7卷 第4期 页码 466-476 doi: 10.1007/s11709-013-0219-5
苏中元,贾民平,许飞云,胡建中
《中国工程科学》 2006年 第8卷 第9期 页码 57-60
论述了未知循环频率的周期平稳信号循环双谱的估计方法;研究了在循环双谱的循环累积量计算中涉及变量的简化存储方法,提出了该变量矩阵是对称阵,通过算法可以三角阵的元素来表述,克服了循环双谱传统估计方法计算量较大的缺陷,提高了运算效率;提出了循环双谱对调相故障信号的分析能力,以及对加性噪声的处理能力,仿真并验证了该方法的有效性,并将其应用于旋转机械状态分析。
Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation
Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,
《工程(英文)》 doi: 10.1016/j.eng.2023.01.015
关键词: Antifreeze peptides Evolution analysis Ice recrystallization inhibition Molecular dynamics simulation Cryopreservation Synthetic biology
电中性固体表面上多条肽链的吸附过程——粗粒化模拟研究 Research
裘若桑, 肖杰, 陈晓东
《工程(英文)》 2020年 第6卷 第2期 页码 185-194 doi: 10.1016/j.eng.2018.12.012
蛋白质在固体表面的吸附过程涉及诸多复杂的分子间相互作用,因此到目前为止仍然无法做到精准调控。通过模拟计算,可以获取固-液界面分子尺度的蛋白质移动机理,从而为预测蛋白质吸附和结垢现象提供可靠的理论依据。本研究通过多尺度粗粒化模型对多条疏水的丙氨酸十二肽在金表面的聚集和吸附过程进行了分析。大约有一半(46.6%)的丙氨酸十二肽可以组成聚集体。30.0%的独立肽链会被快速地吸附到固体表面。这些在表面吸附的肽链经过一段时间的爬行,其中的一些(51.0%)能与吸附在表面的或是游离在溶液中的肽链融合,从而形成吸附在表面的聚集体。这些在固-液界面吸附的肽链使得固体表面性质发生变化。这一变化可能会进一步影响之后溶液中肽链和聚集体在金表面的吸附。本研究揭示的多条肽链吸附机理有希望为进一步研究多个蛋白质分子在固体表面的吸附机理提供理论基础。
Experimental research on seismic behavior of recycled concrete frame under varying cyclic loading
SUN Yuedong, XIAO Jianzhuang, ZHOU Deyuan
《结构与土木工程前沿(英文)》 2008年 第2卷 第4期 页码 302-308 doi: 10.1007/s11709-008-0050-6
关键词: different aggregate stiffness practical application % recycled
Cyclic behavior of prefabricated reinforced concrete frame with infill slit shear walls
Kui XIAO,Qilin ZHANG,Bin JIA
《结构与土木工程前沿(英文)》 2016年 第10卷 第1期 页码 63-71 doi: 10.1007/s11709-015-0294-x
关键词: slit shear wall constitutive model cyclic seismic damage
姜振海
《中国工程科学》 2012年 第14卷 第4期 页码 77-82
针对萨北开发区油层沉积特点及特高含水期剩余油分布特点,以水动力学原理为指导,在已有周期注水实践经验的基础上,结合数值模拟进行机理研究,优化周期注采方式及各项参数,引入了分层段交叉注采改变液流方向改善开发效果的做法,在实践中取得了较好的效果。
标题 作者 时间 类型 操作
Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid
Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun
期刊论文
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
期刊论文
Cystine oligomers successfully attached to peptide cysteine-rich fibrils
Christian Bortolini,Mingdong Dong
期刊论文
Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
null
期刊论文
The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
期刊论文
An enhanced damage plasticity model for predicting the cyclic behavior of plain concrete under multiaxial
Mohammad Reza AZADI KAKAVAND, Ertugrul TACIROGLU
期刊论文
Isogeometric analysis of coupled thermo-elastodynamic problems under cyclic thermal shock
Asghar AMANI DASHLEJEH
期刊论文
Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous
Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG
期刊论文
Prediction of cyclic large plasticity for prestrained structural steel using only tensile coupon tests
Liang-Jiu JIA, Tsuyoshi KOYAMA, Hitoshi KUWAMURA
期刊论文
Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation
Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,
期刊论文
Experimental research on seismic behavior of recycled concrete frame under varying cyclic loading
SUN Yuedong, XIAO Jianzhuang, ZHOU Deyuan
期刊论文
Cyclic behavior of prefabricated reinforced concrete frame with infill slit shear walls
Kui XIAO,Qilin ZHANG,Bin JIA
期刊论文